A group out of Buck Institute for Research on Aging in California have shown that Alpha-Ketoglutarate (AKG), a compound found in common bodybuilding supplements, has tremendous health benefits for ageing mice.
Groups of 18 month old mice were fed a daily portion of AKG over a maximum period of 21 months. The portion roughly comprised 2% of their total daily intake.
According to Azar Asadi Shahmirzadi, a postdoc at the Buck Institute, physiological differences became apparent within a few months:
“They looked much blacker, shinier, and younger [than the control mice who were not fed AKG]”
In addition to the cosmetic benefits, the AKG-fed mice scored an average of 40% higher on tests of strength and vigour. These tests comprised of over 30 different examinations including grip-strength, walking gait, hearing, and hair colour. Remarkably, the female mice that were fed AKG also lived 8–20% longer than the control mice. This extended life-span is thought to be a product of a reduction in systemic inflammation brought about by AKG ingestion.
One the researchers, Brian Kennedy, plans on soon investigating the potential health benefits of AKG in ageing human volunteers. If all goes well, Alpha-Ketoglutarate may be the next big thing in anti-ageing treatment.